Gene amplifications at chromosome 7 of the human gastric cancer genome

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Gene amplifications at chromosome 7 of the human gastric cancer genome.

Genetic aberrations at chromosome 7 are known to be related with diverse human diseases, including cancer and autism. In a number of cancer research areas involving gastric cancer, several comparative genomic hybridization studies employing metaphase chromosome or BAC clone microarrays have repeatedly identified human chromosome 7 as containing 'regions of changes' related with cancer progressi...

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Association of rs9122 Polymorphism in the MCC Gene with Increasing the Risk of Gastric Cancer

Abstract Background and Aim: Gastric cancer is one of the most common malignancies in the world. Genetic background is known to be one of the risk factors for gastric cancer. One of the genes that have been shown to be involved in various cancers, including gastric cancer, is the MCC gene. There are many SNPs in the MCC gene in the encoding and regulatory regions, one of which is rs9122, which ...

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Human chromosome 7 circa 2004: a model for structural and functional studies of the human genome.

Human chromosome 7 is arguably amongst the most comprehensively characterized segments of the human genome. By microscopic examination, it belongs to the medium-sized group C submetacentric class, and historical studies involving chromosome-length measurements estimated that it accounts for approximately 5.3% of the human genome (or 160 Mb). Early successes in molecular genetics led to the iden...

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Human PEG1/MEST, an imprinted gene on chromosome 7.

The mouse Peg1/Mest gene is an imprinted gene that is expressed particularly in mesodermal tissues in early embryonic stages. It was the most abundant imprinted gene among eight paternally expressed genes (Peg 1-8) isolated by a subtraction-hybridization method from a mouse embryonal cDNA library. It has been mapped to proximal mouse chromosome 6, maternal duplication of which causes early embr...

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ژورنال

عنوان ژورنال: International Journal of Molecular Medicine

سال: 2007

ISSN: 1107-3756,1791-244X

DOI: 10.3892/ijmm.20.2.225